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Wando Mount Pleasant Library
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Azacitidine Pre-Treatment Followed by Reduced-Intensity Stem Cell Transplantation in Patients with Higher-Risk Myelodysplastic Syndrome.
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- Author(s): ahn, Jae-Sook; Kim, Yeo-Kyeoung; Min, Yoo Hong; Cheong, June-Won; Jang, Jun Ho; Jung, Chul Won; Kim, In Ho; Yoon, Hwi-Joong; Lee, Hong Ghi; Sohn, Sang Kyun; Moon, Joon Ho; Kim, Hawk; Kim, Yoo-Jin; Won, Jong-Ho; Chung, Joo-Seop; Mun, Yeung Chul; Lee, Je-Hwan; Kim, Hyeoung-Joon
- Source:
Acta Haematologica; Jun2015, Vol. 134 Issue 1, p40-48, 9p, 2 Charts, 3 Graphs- Subject Terms:
- Source:
- Additional Information
- Abstract: Azacitidine (AZA) is commonly used in patients with myelodysplastic syndrome (MDS). To determine the role of AZA before allogeneic stem cell transplantation (allo-SCT), we conducted a prospective study of AZA pre-treatment followed by allo-SCT in patients with higher-risk MDS. Twenty-one patients who were scheduled for their third to sixth cycle of AZA pre-treatment followed by allo-SCT were enrolled. AZA pre-treatment was interrupted early in 3 patients (14.3%) because of leukaemic transformation or death. The overall response rate to AZA pre-treatment was 57.1%. There were 2 cases of complete remission, 1 case of partial remission, and 9 cases of haematologic improvement. Fourteen patients (66.7%) received the planned allo-SCT and 5 patients were alive at the last follow-up. Three-year progression-free survival (PFS) and 3-year overall survival (OS) in the 14 patients who received allo-SCT were 30.0% (95% CI 3.3-56.7) and 42.9% (95% CI 17.1-68.7), respectively. PFS and OS were not influenced by response to AZA pre-treatment (p > 0.05). In this study, AZA had a role as a bridge therapy to prevent leukaemic transformation prior to selection of a donor for allo-SCT and showed low toxicity. It may be considered in patients with higher-risk MDS. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Acta Haematologica is the property of Karger AG and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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