The authors reflect on the low-density lipoprotein (LDL) hypothesis of decreasing LDL cholesterol for reducing atherosclerotic vascular events. The authors agree that findings of Improved Reduction of Outcomes: Vytorin Efficacy International Trials (IMPROVE-IT) indicate that PCSK9 gene can help lower LDL-receptor degradation . An overview of the IMPROVE-IT trial is given. The authors agree that LDL hypothesis should be the LDL principle based on journal-published results of IMPROVE-IT trials.
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