Dopamine mediates circadian rhythms of rod-cone dominance in the Japanese quail retina.

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  • Author(s): Manglapus MK;Manglapus MK; Iuvone PM; Underwood H; Pierce ME; Barlow RB
  • Source:
    The Journal of neuroscience : the official journal of the Society for Neuroscience [J Neurosci] 1999 May 15; Vol. 19 (10), pp. 4132-41.
  • Publication Type:
    Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Society for Neuroscience Country of Publication: United States NLM ID: 8102140 Publication Model: Print Cited Medium: Internet ISSN: 1529-2401 (Electronic) Linking ISSN: 02706474 NLM ISO Abbreviation: J Neurosci Subsets: MEDLINE
    • Publication Information:
      Publication: Washington, DC : Society for Neuroscience
      Original Publication: [Baltimore, Md.] : The Society, c1981-
    • Subject Terms:
      Adaptation, Ocular*; Circadian Rhythm/*physiology ; Coturnix/*physiology ; Photoreceptor Cells, Vertebrate/*physiology; Animals ; Dihydroxyphenylalanine/metabolism ; Electroretinography
    • Abstract:
      A circadian clock modulates the functional organization of the Japanese quail retina. Under conditions of constant darkness, rods dominate electroretinogram (ERG) b-wave responses at night, and cones dominate them during the day, yielding a circadian rhythm in retinal sensitivity and rod-cone dominance. The activity of tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis, also exhibits a circadian rhythm in the retina with approximately threefold higher levels during the day than at night. The rhythm of tyrosine hydroxylase activity is opposite in phase to the circadian activity of tryptophan hydroxylase, the first enzyme in the melatonin biosynthetic pathway. We tested whether dopamine may be related to the physiological rhythms of the retina by examining the actions of pharmacological agents that effect dopamine receptors. We found that blocking dopamine D2 receptors in the retina during the day mimics the nighttime state by increasing the amplitude of the b-wave and shifting the retina to rod dominance. Conversely, activating D2 receptors at night mimics the daytime state by decreasing the amplitude of the b-wave and shifting the retina to cone dominance. A selective antagonist for D1 dopamine receptors has no effect on retinal sensitivity or rod-cone dominance. Reducing retinal dopamine partially abolishes rhythms in sensitivity and yields a rod-dominated retina regardless of the time of day. These results suggest that dopamine, under the control of a circadian oscillator, has a key role in modulating sensitivity and rod-cone dominance in the Japanese quail retina.
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    • Grant Information:
      R01 EY004864 United States EY NEI NIH HHS; R56 EY000667 United States EY NEI NIH HHS; R01 EY000667 United States EY NEI NIH HHS; EY 00667 United States EY NEI NIH HHS; EY 10672 United States EY NEI NIH HHS; EY 04864 United States EY NEI NIH HHS
    • Accession Number:
      63-84-3 (Dihydroxyphenylalanine)
    • Publication Date:
      Date Created: 19990511 Date Completed: 19990601 Latest Revision: 20240720
    • Publication Date:
      20240720
    • Accession Number:
      PMC6782696
    • Accession Number:
      10234041