[The interrelation of neural and humoral cardiogenic influences and their action on the blood circulation].

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  • Author(s): Pavliuchenko VB;Pavliuchenko VB
  • Source:
    Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994) [Fiziol Zh (1994)] 1999; Vol. 45 (1-2), pp. 56-63.
  • Publication Type:
    Comparative Study; English Abstract; Journal Article
  • Language:
    Ukrainian
  • Additional Information
    • Transliterated Title:
      Vzaiemozv'iazok nervovykh i humoral'nykh kardiohennykh vplyviv i ïkh dia na krovobih.
    • Source:
      Publisher: Naukova Dumka Country of Publication: Ukraine NLM ID: 9601541 Publication Model: Print Cited Medium: Print ISSN: 2522-9028 (Print) Linking ISSN: 25229028 NLM ISO Abbreviation: Fiziol Zh (1994) Subsets: MEDLINE
    • Publication Information:
      Publication: Kyiv : Naukova Dumka
      Original Publication: Kyïv : Nauk. dumka, 1994-
    • Subject Terms:
      Blood Circulation/*physiology ; Heart/*physiology ; Neurotransmitter Agents/*physiology; Animals ; Blood Circulation/drug effects ; Cats ; Dogs ; Heart/drug effects ; Heart/innervation ; Nitric Oxide/physiology ; Nitric Oxide Synthase/antagonists & inhibitors ; Nitric Oxide Synthase/physiology ; Reflex/drug effects ; Reflex/physiology
    • Abstract:
      The role of some endogenous bioregulators in formation of cardiogenic reflectory effects on circulation were investigated in acute experiments on anesthetized animals with using various methods (direct recording of impulse activity from cardiac afferent nerves, humoral isolation of the heart). Interrelations between development of cardiogenic depressor reactions and nitric oxide production was established. Systemic inhibition of NOS led to decrease in dilatation of coronary and peripheral vessels. At the other hand dramatic suppression of cardiogenic depressor reflexes followed by inhibition of prostacyclin production. The data support the essential role of endogenous bioactive substances in formation of cardiogenic reflex effects on circulation in physiological and pathological states. We also suggest that a mayor metabolite of arachidonic acid--prostacyclin--is modulator and one of humoral components of the vagus-mediated cardiogenic depressor reflex in physiological conditions.
    • Accession Number:
      0 (Neurotransmitter Agents)
      31C4KY9ESH (Nitric Oxide)
      EC 1.14.13.39 (Nitric Oxide Synthase)
    • Publication Date:
      Date Created: 19981208 Date Completed: 19990506 Latest Revision: 20131121
    • Publication Date:
      20221213
    • Accession Number:
      10202637