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Spectra Optia granulocyte apheresis collections result in higher collection efficiency of viable, functional neutrophils in a randomized, crossover, multicenter trial.
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- Author(s): Cancelas, Jose A.; Padmanabhan, Anand; Le, Tuan; Ambruso, Daniel R.; Rugg, Neeta; Worsham, D. Nicole; Pinkard, Susan L.; Graminske, Sharon; Buck, Jennifer; Goldberg, Julie; Bill, Jerry
- Source:
Transfusion; Apr2015, Vol. 55 Issue 4, p748-755, 8p, 2 Diagrams, 4 Charts- Subject Terms:
HEMAPHERESIS; GRANULOCYTES; NEUTROPENIA; NEUTROPHILS; GRANULOCYTE colony stimulating factor receptor; CELL survival; BLOOD donors; THERAPEUTICS; CENTRIFUGATION; AUTOMATION; CELL physiology; COMPARATIVE studies; CROSSOVER trials; RED blood cell transfusion; GRANULOCYTE-colony stimulating factor; LEUKAPHERESIS; LONGITUDINAL method; RESEARCH methodology; MEDICAL cooperation; ORGAN donors; RESEARCH; RESEARCH funding; PRODUCT design; EVALUATION research; RANDOMIZED controlled trials; DEXAMETHASONE; LEUKOCYTE count; EQUIPMENT & supplies - Source:
- Additional Information
- Abstract:
Background: Granulocyte transfusion from healthy donors is used in the treatment of patients with granulocyte function defects, or transient neutropenia and severe bacterial or fungal infections resistant to maximal antimicrobial treatment.Study Design and Methods: This study evaluated the performance and safety of the newly developed granulocyte collection protocol of the Spectra Optia in a prospective, multicenter, open-label, randomized, paired crossover trial compared with the COBE Spectra apheresis system in a population of 32 evaluable healthy subjects. All subjects received granulocyte-colony-stimulating factor and dexamethasone before collection.Results: Granulocyte procedures from Spectra Optia apheresis procedures had an approximately 23% higher polymorphonuclear (PMN) collection efficiency (CE) than the COBE Spectra collections (mean, 53.7% vs. 43.2%; p < 0.01), while the platelet CE (10.9% vs. 10.8%, respectively) and hematocrit (7.4% vs. 7.4%) were comparable between collections on both devices. Spectra Optia collections generated a higher total PMN yield per liter of blood processed than those produced by the COBE Spectra (with means of 8.6 × 10(10) vs. 6.8 × 10(10) , respectively). Granulocyte viability was more than 99% with both devices, and chemotaxic and bacterial killing activities of circulating versus collected granulocytes were similarly preserved. Fewer operator adjustments were required with Spectra Optia and there was no significant difference in the number or intensity of adverse events between instruments.Conclusion: CE of the granulocyte collection procedure with the Spectra Optia was approximately 10 percentage points higher than with the COBE Spectra, required less operator involvement, and is safe for clinical implementation. [ABSTRACT FROM AUTHOR] - Abstract: Copyright of Transfusion is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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