The effects of bovine respiratory syncytial on normal ovine lymphocyte responses to mitogens or antigens in vitro.

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  • Author(s): Keles I;Keles I; Sharma AK; Woldehiwet Z; Murray RD
  • Source:
    Comparative immunology, microbiology and infectious diseases [Comp Immunol Microbiol Infect Dis] 1999 Jan; Vol. 22 (1), pp. 1-13.
  • Publication Type:
    Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 7808924 Publication Model: Print Cited Medium: Print ISSN: 0147-9571 (Print) Linking ISSN: 01479571 NLM ISO Abbreviation: Comp Immunol Microbiol Infect Dis Subsets: MEDLINE
    • Publication Information:
      Publication: Exeter : Elsevier Science Ltd
      Original Publication: Oxford, Elmsford, N. Y., Pergamon Press.
    • Subject Terms:
      Lymphocyte Activation*; Antigens, Viral/*pharmacology ; Lymphocytes/*immunology ; Mitogens/*pharmacology ; Respiratory Syncytial Virus Infections/*immunology ; Respiratory Syncytial Virus, Bovine/*immunology; Animals ; Border disease virus/immunology ; Cattle ; Cells, Cultured ; Concanavalin A/pharmacology ; Dinoprostone/pharmacology ; Lymphocytes/drug effects ; Phytohemagglutinins/pharmacology ; Pokeweed Mitogens/pharmacology ; Sheep ; Tumor Necrosis Factor-alpha/pharmacology
    • Abstract:
      In the present study peripheral blod mononuclear cells (MNC) obtained from normal uninfected lambs were used to study the possible effects of bovine respiratory syncytial virus (BRSV) on lymphocyte responses to the mitogens, phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM) in vitro. Live BRSV had a depressive effect on the proliferative responses of normal MNC to PHA, Con A and PWM. Inactivated BRSV and a commercial preparation of prostaglandin E2 were also found to depress the proliferative responses of normal ovine MNC to PHA but recombinant tumour necrosis factor-alpha (TNF-alpha) had no such effect. Serum samples obtained from BRSV-infected lambs contained substances inhibitory to PHA-driven lymphocyte blastogenesis. Memory blastogenic responses to border disease virus (BDV) of lymyphocytes obtained from lambs previously primed with BDV were significantly reduced when lymphocytes were exposed to infectious BRSV.
    • Accession Number:
      0 (Antigens, Viral)
      0 (Mitogens)
      0 (Phytohemagglutinins)
      0 (Pokeweed Mitogens)
      0 (Tumor Necrosis Factor-alpha)
      11028-71-0 (Concanavalin A)
      K7Q1JQR04M (Dinoprostone)
    • Publication Date:
      Date Created: 19990331 Date Completed: 19990513 Latest Revision: 20191024
    • Publication Date:
      20240829
    • Accession Number:
      10.1016/s0147-9571(98)00023-x
    • Accession Number:
      10099024