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Variantes genotípicas del SNP -19 del gen de la CAPN 10 y su relación con la diabetes mellitus tipo 2 en una población de Ciudad Juárez, México.
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- Author(s): Loya Méndez, Yolanda1 ; Reyes Leal, Gilberto1; Sánchez González, Adriana1; Portillo Reyes, Verónica1; Reyes Ruvalcaba, David1; Bojórquez Rangel, Guillermo1
- Source:
Nutrición Hospitalaria. feb2015, Vol. 31 Issue 2, p744-750. 7p. - Source:
- Additional Information
- Alternate Title: SNP-19 GENOTYPIC VARIANTS OF CAPN 10 GENE AND ITS RELATION TO DIABETES MELLITUS TYPE 2 IN A POPULATION OF CIUDAD JUAREZ, MEXICO.
- Subject Terms:
- Abstract: Introducción: La diabetes mellitus (DM) tipo 2 es una patología común de origen multifactorial cuyas bases genéticas exactas se desconocen aún; diversos estudios sugieren que los polimorfismos de nucleótido único (SNPs) en el gen CAPN10 (Locus 2q37.3) podrían participar en su desarrollo, incluyendo el polimorfismo de inserción/delación SNP-19 (2R→3R).Objetivo: Determinar la relación entre el polimorfismoSNP-19 y la presencia de DM tipo 2 en una población de Ciudad Juárez. Métodos: Se seleccionaron 107 individuos: 43 diabéticos tipo 2 (casos) y 64 no diabéticos sin antecedentes heredo-familiares de DM tipo 2 en primer grado (control). Se realizó estudio antropométrico y perfil bioquímico de lípidos, lipoproteínas y glucosa sérica. Se extrajo ADN de linfocitos de sangre periférica y se amplificó mediante la técnica de reacción en cadena de la polimerasa (PCR). Se analizaron los genotipos del polimorfismo SNP-19 del gen CAPN10por análisis electroforético en geles de agarosa. Se calcularon las frecuencias genotípicas y alélicas y se realizaron pruebas de equilibrio de Hardy-Weinberg (GenAlEx 6.4).Resultados: El análisis mediante la prueba X2 identificó diferencias en los genotipos entre casos y control, con una mayor frecuencia del genotipo homocigoto 3Rdel SNP-19 en el grupo de casos (0.418) respecto al grupo control (0.265). El genotipo 2R/3R presentó relación con valores elevados de peso, índice de masa corporal y perímetros de cintura y cadera; pero solo en el grupo de diabéticos (P=< 0.05).Conclusión: Los resultados de esta investigación sugieren la participación del SNP-19 del gen CAPN10 en el desarrollo de DM tipo 2 en la población estudiada. [ABSTRACT FROM AUTHOR]
- Abstract: Introduction: Diabetes Mellitus (DM) type 2 is a common pathology with multifactorial etiology, which exact genetic bases remain unknown. Some studies suggest that single nucleotides polymorphisms (SNPs) in the CAPN10 gene (Locus 2q37.3) could be associated with the development of this disease, including the insertion/deletion polymorphism SNP-19 (2R→3R).Objective: The present study determined the association between the SNP-19 and the risk of developing DM type 2 in Ciudad Juarez population. Methodology: For this study 107 participants were selected: 43 diabetics type 2 (cases) and 64 non diabetics with no family history of DM type 2 in first grade (control). Anthropometric studies were realized as well as lipids, lipoproteins and serum glucose biochemical profiles. The genotypification of SNP-19 was performed using peripheral blood lymphocytes DNA, polymerase chain reactions (PCR), and electrophoretic analysis in agarose gels. Once obtained the genotypic and allelic frequencies, the Hardy-Weinberg equilibrium test (GenAlEx 6.4) was also performed. Results: Using the X2 analysis it was identified the genotypic differences between cases and control with higher frequency of the homozygous genotype 3R of SNP-19 in the cases group (0.418) compared to control group (0.265). Also, it was observed an association between genotype 2R/3R with elevated weight, body mass index, and waist and hip circumferences, but only in the diabetic group (P=< 0.05).Conclusion: The findings in this study suggest thatSNP-19 in CAPNIO may participate in the development of DM type 2 in the studied population. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Nutrición Hospitalaria is the property of Sociedad Espanola de Nutricion Parenteral y Enteral and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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