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Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist.
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- Additional Information
- Source:
Publisher: George Thieme Country of Publication: Germany NLM ID: 0066751 Publication Model: Print Cited Medium: Print ISSN: 0032-0943 (Print) Linking ISSN: 00320943 NLM ISO Abbreviation: Planta Med Subsets: MEDLINE
- Publication Information:
Publication: Stuttgart ; New York : George Thieme
Original Publication: Stuttgart, Hippokrates Verlag.
- Subject Terms:
- Abstract:
We investigated the effect of a new PAF antagonist pinusolide, isolated from the leaves of Biota orientalis, on PAF-induced [3H]serotinin release from rabbit platelets, hypotension and vascular permeability. Pinusolide (IC50, about 5 x 10(-6) M) inhibited specifically [3H]serotinin release from rabbit platelets when stimulated with PAF (5 x 10(-8) M), but showed no effect when induced by ADP, collagen, and thrombin. It also inhibited PAF-induced hypotension in a dose-dependent manner in rats with no effect on the hypotension induced by acetylcholine, histamine and serotonin. The inhibitory effect of pinusolide on the PAF-induced vascular permeability is less specific than the induced hypotension. These results suggest that pinusolide may prove of therapeutic value in the treatment of hypotension and a molecular design of pinusolide analogues may provide the possibility of a new PAF specific antagonists.
- Accession Number:
0 (Diterpenes)
0 (Platelet Activating Factor)
31685-80-0 (pinusolide)
- Publication Date:
Date Created: 19990320 Date Completed: 19990415 Latest Revision: 20191103
- Publication Date:
20231215
- Accession Number:
10.1055/s-1999-13959
- Accession Number:
10083843
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