Enzymic evaluation of thiamin, riboflavin and pyridoxine status of parturient mothers and their newborn infants in a Mediterranean area of Spain.

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  • Additional Information
    • Source:
      Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8804070 Publication Model: Print Cited Medium: Print ISSN: 0954-3007 (Print) Linking ISSN: 09543007 NLM ISO Abbreviation: Eur J Clin Nutr Subsets: MEDLINE
    • Publication Information:
      Publication: <2003->: London : Nature Publishing Group
      Original Publication: London : J. Libbey, c1988-
    • Subject Terms:
      Nutritional Status*; Infant, Newborn/*physiology ; Postpartum Period/*physiology ; Pyridoxine/*blood ; Riboflavin/*blood ; Thiamine/*blood; Adolescent ; Adult ; Aspartate Aminotransferases/blood ; Female ; Fetal Blood/enzymology ; Flavin-Adenine Dinucleotide/chemistry ; Glutathione Reductase/blood ; Glycated Hemoglobin/analysis ; Humans ; Infant Nutritional Physiological Phenomena ; Infant, Newborn/blood ; Male ; Postpartum Period/blood ; Pregnancy ; Pyridoxal Phosphate/chemistry ; Spain ; Statistics, Nonparametric ; Thiamine Pyrophosphate/chemistry ; Transketolase/blood
    • Abstract:
      Objective: To determine the biochemical status of thiamin, riboflavin and pyridoxine in parturient mothers and their newborn infants in a Mediterranean region.
      Design: Transveral study.
      Setting: St Joan University Hospital and Faculty of Medicine & Health Sciences, Universitat Rovira i Virgili, Reus, Spain.
      Subjects: 131 healthy parturient mothers, with normal pregnancies and deliveries in St Joan University Hospital, and their newborn infants.
      Interventions: Erythrocyte haemolysates were prepared from maternal blood at delivery and infants' umbilical cord blood and used to measure micronutrient status using the transketolase, glutathione reductase and aspartate aminotransferase coenzyme stimulation tests.
      Results: Maternal and infant coenzyme activities were significantly correlated, but infant coenzyme status was better than maternal, with significantly higher basal and stimulated activity (P < 0.001) and significantly lower activation coefficients (P < 0.001). Inadequate thiamin, riboflavin or pyridoxine status occured in 38.2 62.6% (50-82) of the mothers and 3.1-37.4% (4 49) of the infants; 85.2% (46/54), 12.9% (4/31) and 24.1% (12/54) of infants born to mothers with biochemical deficiency of either thiamin, riboflavin or pyridoxine, respectively also had inadequate status. Maternal deficiencies in more than one vitamin further increased the risk of infant thiamin and pyridoxine deficiency. Maternal and infant riboflavin status were significantly correlated with fetal development (e.g. length at birth, P < 0.001). The incidence of thiamin deficiency in paturient mothers in Spain was the highest out of a 12-country comparison.
      Conclusions: Inadequate status for each vitamin was evident in mothers and infants. Maternal status of each individual vitamin, but especially riboflavin, was affected by maternal status of the other vitamins. Infant thiamin status was the most adversely affected by maternal deficiencies in more than one vitamin. Infant riboflavin status, however, was apparently protected from adverse maternal status.
    • Accession Number:
      0 (Glycated Hemoglobin A)
      146-14-5 (Flavin-Adenine Dinucleotide)
      5V5IOJ8338 (Pyridoxal Phosphate)
      EC 1.8.1.7 (Glutathione Reductase)
      EC 2.2.1.1 (Transketolase)
      EC 2.6.1.1 (Aspartate Aminotransferases)
      KV2JZ1BI6Z (Pyridoxine)
      Q57971654Y (Thiamine Pyrophosphate)
      TLM2976OFR (Riboflavin)
      X66NSO3N35 (Thiamine)
    • Publication Date:
      Date Created: 19990227 Date Completed: 19990429 Latest Revision: 20221207
    • Publication Date:
      20221213
    • Accession Number:
      10.1038/sj.ejcn.1600674
    • Accession Number:
      10048797