Vaccine-elicited CD4 T cells induce immunopathology after chronic LCMV infection.

IMMUNOLOGY; LYMPHOCYTIC choriomeningitis; EFFECT of drugs on T cells; CD4 antigen; NATURAL immunity; IMMUNOPATHOLOGY; IMMUNE response; IMMUNOLOGY of inflammation; VACCINATION

CD4 T cells promote innate and adaptive immune responses, but how vaccine-elicited CD4 T cells contribute to immune protection remains unclear. We evaluated whether induction of virus-specific CD4 T cells by vaccination would protect mice against infection with chronic lymphocytic choriomeningitis virus (LCMV). Immunization with vaccines that selectively induced CD4 T cell responses resulted in catastrophic inflammation and mortality after challenge with a persistent strain of LCMV. Immunopathology required antigen-specific CD4 T cells and was associated with a cytokine storm, generalized inflammation, and multi-organ system failure. Virus-specific CD8 T cells or antibodies abrogated the pathology. These data demonstrate that vaccine-elicited CD4 T cells in the absence of effective antiviral immune responses can trigger lethal immunopathology. [ABSTRACT FROM AUTHOR]

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