The associations between exposure to ambient air pollution and coagulation markers and the potential effects of DNA methylation.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9422688 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-3336 (Electronic) Linking ISSN: 03043894 NLM ISO Abbreviation: J Hazard Mater Subsets: MEDLINE
    • Publication Information:
      Original Publication: Amsterdam : Elsevier,
    • Subject Terms:
      DNA Methylation* ; Biomarkers*/blood ; Particulate Matter*/analysis ; Particulate Matter*/toxicity ; Air Pollutants*/toxicity ; Air Pollutants*/analysis ; Plasminogen Activator Inhibitor 1*/genetics ; Plasminogen Activator Inhibitor 1*/blood ; Air Pollution*/adverse effects ; Air Pollution*/analysis; Humans ; Male ; Middle Aged ; Female ; China ; Blood Coagulation/drug effects ; Fibrinogen/analysis ; Fibrinogen/metabolism ; Environmental Exposure/adverse effects ; CpG Islands ; Aged ; Adult
    • Abstract:
      Previous studies have illustrated the pivotal role of coagulation biomarkers in the link between air pollution and cardiovascular disease (CVD). However, inconsistencies remain in the conclusions, with limited studies conducted in rural areas of China. We conducted a panel study in rural areas of Henan Province, China. Considering the potential effect modifications of atherosclerotic cardiovascular disease (ASCVD) risks, 104 participants were enrolled, comprising two matched groups: 52 with high ASCVD risks and 52 with low ASCVD risks. DNA methylation at CpG sites and coagulation indices were measured for all participants. Linear mixed-effect regression models were used to evaluate the associations between ambient air pollution, coagulation biomarkers, and DNA methylation. We observed that for every 5-day standard deviation (SD) increment of PM 2.5 (11.91 μg/m³) and PM 10 (13.65 μg/m³), fibrinogen increased by 7.70 % (95 %CI: 2.27, 13.12) and 8.50 % (95 %CI: 2.46, 14.55), respectively. SO 2 (6.95 μg/m³) was associated with 40.25 % (95 %CI: 14.83, 65.67) increase in plasminogen activator inhibitor-1 (PAI-1). Decreased methylation at CpG sites was associated with exposure to air pollution. However, DNA methylation did not mediate the association between ambient air pollution and coagulation. Our study revealed the harmful impact of ambient air pollution on coagulation function but found no significant mediation effects of DNA methylation.
      Competing Interests: Declaration of Competing Interest The author declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Ambient air pollution; Coagulation biomarkers; DNA methylation; Mediation effects; Panel study
    • Accession Number:
      0 (Biomarkers)
      0 (Particulate Matter)
      0 (Air Pollutants)
      0 (Plasminogen Activator Inhibitor 1)
      9001-32-5 (Fibrinogen)
    • Publication Date:
      Date Created: 20241114 Date Completed: 20241130 Latest Revision: 20241130
    • Publication Date:
      20241202
    • Accession Number:
      10.1016/j.jhazmat.2024.136433
    • Accession Number:
      39541886