Link Between Metabolic Syndrome, Blood Lipid Markers, Dietary Lipids, and Survival in Women with Early-Stage Breast Cancer.

Publisher: MDPI Publishing Country of Publication: Switzerland NLM ID: 101521595 Publication Model: Electronic Cited Medium: Internet ISSN: 2072-6643 (Electronic) Linking ISSN: 20726643 NLM ISO Abbreviation: Nutrients Subsets: MEDLINE

Original Publication: Basel, Switzerland : MDPI Publishing

Breast Neoplasms*/mortality ; Breast Neoplasms*/blood ; Metabolic Syndrome*/blood ; Metabolic Syndrome*/mortality ; ATP Binding Cassette Transporter, Subfamily G, Member 1*/genetics ; ATP Binding Cassette Transporter, Subfamily G, Member 1*/metabolism ; Lipids*/blood; Humans ; Female ; Middle Aged ; Dietary Fats/administration & dosage ; Adult ; ATP Binding Cassette Transporter 1/genetics ; Aged ; Neoplasm Staging ; Disease-Free Survival ; Biomarkers/blood

Background/objectives: Nearly 10% of cancers could be prevented through dietary changes. In addition, breast cancer (BC) is the most common cancer in women worldwide. Inadequate diet may lead to several metabolic abnormalities, including metabolic syndrome (MS). The goal of our study is to evaluate the link between survival after BC and MS, as well as diet lipids and circulating lipids.
Methods: This study was performed in an early-stage BC cohort (n = 73): MS, dietary lipids, and circulating biological parameters, including leucocyte expression in cholesterol carriers (ATP-binding cassette transporter ABCA1, ABCG1), were determined before any medication intervention. The data of each patient were analyzed using univariate logistic regression and are expressed by HR, 95%CI [5th-95th]. All these parameters were explored with survival parameters using Cox regression analyses.
Results: Overall survival (OS) and invasive disease-free survival (iDFS) were significantly longer for the women without metabolic syndrome with HR 4.7 [1.11-19.92] and p = 0.036, and 3.58 [1.23-10.44] and p = 0.019, respectively. The expression of ABCG1 in peripheral leucocytes, an ATP-binding cassette transporter involved in cholesterol and phospholipid trafficking, is significantly associated with iDFS (1.38 [1.1-1.9], p = 0.0048). MS is associated with more pejorative survival parameters in early-stage breast cancer. Paraoxonase (or PON) activities differ according to PON gene polymorphism, but also diet. A link between PON activities and survival parameters was suggested and needs to be clarified.
Conclusions: This study emphasizes the link between survival parameters of early-stage breast cancer, metabolic syndrome, and some parameters related to lipid metabolism.

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PHRC Ministère de la Santé PHRC

Keywords: breast cancer; dietary habits; lipids; metabolic syndrome; nutrition; paraoxonase

0 (ATP Binding Cassette Transporter, Subfamily G, Member 1)
0 (Lipids)
0 (Dietary Fats)
0 (ABCG1 protein, human)
0 (ATP Binding Cassette Transporter 1)
0 (ABCA1 protein, human)
0 (Biomarkers)

Date Created: 20241109 Date Completed: 20241109 Latest Revision: 20241116

20241116

PMC11547724

10.3390/nu16213579

39519412