Enhanced Mandibular Bone Repair Using Poly Lactic- co -glycolic Acid Combined with Nanohydroxyapatite Scaffold Loaded by Mesenchymal Stromal/Stem Cells and Curcumin in Male Rats.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 101654670 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2373-9878 (Electronic) Linking ISSN: 23739878 NLM ISO Abbreviation: ACS Biomater Sci Eng Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, DC : American Chemical Society, [2015]-
    • Subject Terms:
      Polylactic Acid-Polyglycolic Acid Copolymer*/chemistry ; Curcumin*/pharmacology ; Curcumin*/chemistry ; Tissue Scaffolds*/chemistry ; Mesenchymal Stem Cells*/drug effects ; Mesenchymal Stem Cells*/cytology ; Durapatite*/chemistry ; Durapatite*/pharmacology ; Mandible*/drug effects; Animals ; Male ; Rats ; Bone Regeneration/drug effects ; Rats, Wistar ; Mesenchymal Stem Cell Transplantation/methods
    • Abstract:
      This study aimed to investigate the healing effect of a polylactic- co -glycolic acid (PLGA) scaffold containing nanohydroxyapatite (NHA) along with curcumin (CCM), loaded with adipose-derived mesenchymal stem cells (AD-MSCs), on mandibular bone defects. The designed PLGA scaffolds containing NHA were evaluated for their mechanical and structural properties. Forty rats were divided into five groups ( n = 8) based on the treatment: Sham, PLGA scaffolds containing NHA, PLGA scaffolds containing NHA + CCM, PLGA scaffolds containing NHA + AD-MSCs, and PLGA scaffolds containing NHA + CCM + AD-MSCs. After 8 weeks' follow-up, mandible bones were isolated for histomorphometry evaluation. Data were analyzed using SPSS version 21, with p -values <0.05 considered statistically significant. SEM evaluation showed that the designed nanocomposite scaffold had 80% porosity. Histomorphometry results indicated a significant difference in osteocyte, osteoblast, bone area, and vascular area parameters in the group treated with scaffolds loaded with AD-MSCs + CCM compared to the other groups ( p < 0.05). The PLGA-containing NHA-CCM nanocomposite scaffold demonstrated good porosity and dispersion, suitable for treating bone defects. Rats treated with scaffolds containing AD-MSCs and CCM showed better therapeutic results than the other groups. Further research is needed to evaluate its anti-inflammatory, antioxidant properties, osteogenesis, and therapeutic effects in larger animal models.
    • Contributed Indexing:
      Keywords: CCM; adipose tissue-derived mesenchymal stem cells; animal model; bone defect; polylactic-co-glycolic acid (PLGA)
    • Accession Number:
      1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
      IT942ZTH98 (Curcumin)
      91D9GV0Z28 (Durapatite)
    • Publication Date:
      Date Created: 20241028 Date Completed: 20241111 Latest Revision: 20241111
    • Publication Date:
      20241114
    • Accession Number:
      10.1021/acsbiomaterials.4c00608
    • Accession Number:
      39467692