Deciphering the hydrodynamics of lipid-coated microbubble sonoluminescence for sonodynamic therapy.

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  • Additional Information
    • Source:
      Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 9433356 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2828 (Electronic) Linking ISSN: 13504177 NLM ISO Abbreviation: Ultrason Sonochem Subsets: MEDLINE
    • Publication Information:
      Publication: Amsterdam : Elsevier Science
      Original Publication: Oxford : Butterworth Heinemann, c1994-
    • Subject Terms:
      Microbubbles* ; Ultrasonic Therapy*/methods ; Hydrodynamics*; Lipids/chemistry ; Luminescence ; Humans
    • Abstract:
      Sonodynamic therapy (SDT) is a minimally invasive targeted cancer therapy that uses focused low-intensity ultrasound (<10 MPa, <10 W/cm 2 ) to activate sonosensitizer drugs. Once activated, these chemical compounds generate reactive oxygen species (ROS) to damage and kill cancer cells. A Phase I clinical trial has shown promising results for treating glioblastoma with SDT. We hypothesize that the efficacy of SDT can be improved by introducing lipid-coated microbubbles that produce a sonochemical effect that enhances ROS production. We investigate the hydrodynamics of a U.S. Food and Drug Administration (FDA)-approved microbubble, Lumason®, and a phospholipid-coated oxygen microbubble to predict the ultrasound parameters that induce sonoluminescence onset in biophysically relevant medium (e.g., water and blood) under clinical SDT conditions. The threshold pressures and frequencies for sonoluminescence with these therapeutic agents lie between 20 kHz - 1 MHz and 0.05 MPa - 1 MPa, respectively. The lipid-coated oxygen microbubble exhibits stronger sonoluminescence than the Lumason® microbubble, suggesting its use for improving SDT efficacy.
      Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
      (Copyright © 2024 The Authors. Published by Elsevier B.V. All rights reserved.)
    • Contributed Indexing:
      Keywords: Glioblastoma; Lipid-coated microbubble; Sonodynamic therapy; Sonoluminescence; Ultrasound
    • Accession Number:
      0 (Lipids)
    • Publication Date:
      Date Created: 20241004 Date Completed: 20241123 Latest Revision: 20241123
    • Publication Date:
      20241126
    • Accession Number:
      PMC11488432
    • Accession Number:
      10.1016/j.ultsonch.2024.107090
    • Accession Number:
      39366089