Bidirectional causality between the levels of blood lipids and endometriosis: a two-sample mendelian randomization study.

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  • Additional Information
    • Source:
      Publisher: BioMed Central Country of Publication: England NLM ID: 101088690 Publication Model: Electronic Cited Medium: Internet ISSN: 1472-6874 (Electronic) Linking ISSN: 14726874 NLM ISO Abbreviation: BMC Womens Health Subsets: MEDLINE
    • Publication Information:
      Original Publication: [London] : BioMed Central, 2001-
    • Subject Terms:
      Endometriosis*/blood ; Endometriosis*/genetics ; Mendelian Randomization Analysis*/methods ; Genome-Wide Association Study* ; Triglycerides*/blood ; Lipids*/blood; Humans ; Female ; Risk Factors ; Causality ; Finland/epidemiology ; Cholesterol/blood
    • Abstract:
      Background: Observational studies have found a correlation between the levels of blood lipids and the development and progression of endometriosis (EM). However, the causality and direction of this correlation is unclear. This study aimed to examine the bidirectional connection between lipid profiles and the risk of EM using publicly available genome-wide association study (GWAS) summary statistics.
      Methods: Eligible exposure variables such as levels of triglycerides (TG), total cholesterol (TC), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were selected using a two-sample Mendelian randomization (MR) analysis method following a series of quality control procedures. Data on EM were obtained from the publicly available Finnish database of European patients. Inverse variance weighted (IVW), MR Egger, weighted median, and weighted mode methods were used to analyze the causal relationship between lipid exposure and EM, exclude confounders, perform sensitivity analyses, and assess the stability of the results. Reverse MR analyses were performed with EM as exposure and lipid results as study outcomes.
      Results: IVW analysis results identified HDL as a protective factor for EM, while TG was shown to be a risk factor for EM. Subgroup analyses based on the site of the EM lesion identified HDL as a protective factor for EM of the uterus, while TG was identified a risk factor for the EM of the fallopian tube, ovary, and pelvic peritoneum. Reverse analysis did not reveal any effect of EM on the levels of lipids.
      Conclusion: Blood lipids, such as HDL and TG, may play an important role in the development and progression of EM. However, EM does not lead to dyslipidemia.
      (© 2024. The Author(s).)
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    • Grant Information:
      2021Y9187 Joint Funds for the innovation of science and Technology; 2021Y9187 Joint Funds for the innovation of science and Technology; 2021Y9187 Joint Funds for the innovation of science and Technology; 2021Y9187 Joint Funds for the innovation of science and Technology; 2021Y9187 Joint Funds for the innovation of science and Technology; 2021Y9187 Joint Funds for the innovation of science and Technology; 2021J01421 Nature Foundation of Fujian Province; 2021J01421 Nature Foundation of Fujian Province; 2021J01421 Nature Foundation of Fujian Province; 2021J01421 Nature Foundation of Fujian Province; 2021J01421 Nature Foundation of Fujian Province; 2021J01421 Nature Foundation of Fujian Province; 2022GGB004 Fujian Provincial Health Commission Young and Middle-aged Backbone Personnel Training Project; 2022GGB004 Fujian Provincial Health Commission Young and Middle-aged Backbone Personnel Training Project; 2022GGB004 Fujian Provincial Health Commission Young and Middle-aged Backbone Personnel Training Project; 2022GGB004 Fujian Provincial Health Commission Young and Middle-aged Backbone Personnel Training Project; 2022GGB004 Fujian Provincial Health Commission Young and Middle-aged Backbone Personnel Training Project; 2022GGB004 Fujian Provincial Health Commission Young and Middle-aged Backbone Personnel Training Project
    • Contributed Indexing:
      Keywords: Blood lipid; Endometriosis; Genome-wide association study; Mendelian; Randomization; The causal effect and single nucleotide polymorphism
    • Accession Number:
      0 (Triglycerides)
      0 (Lipids)
      97C5T2UQ7J (Cholesterol)
    • Publication Date:
      Date Created: 20240704 Date Completed: 20240705 Latest Revision: 20240707
    • Publication Date:
      20240707
    • Accession Number:
      PMC11223312
    • Accession Number:
      10.1186/s12905-024-03213-w
    • Accession Number:
      38965508