Self-Assembled Borneol-Guanidine-Based Amphiphilic Polymers as an Efficient Antibiofilm Agent.

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  • Additional Information
    • Source:
      Publisher: American Chemical Society Country of Publication: United States NLM ID: 101504991 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1944-8252 (Electronic) Linking ISSN: 19448244 NLM ISO Abbreviation: ACS Appl Mater Interfaces Subsets: MEDLINE
    • Publication Information:
      Original Publication: Washington, D.C. : American Chemical Society
    • Subject Terms:
      Biofilms*/drug effects ; Staphylococcus aureus*/drug effects ; Anti-Bacterial Agents*/pharmacology ; Anti-Bacterial Agents*/chemistry ; Anti-Bacterial Agents*/chemical synthesis ; Guanidine*/chemistry ; Guanidine*/pharmacology ; Camphanes*/chemistry ; Camphanes*/pharmacology ; Polymers*/chemistry ; Polymers*/pharmacology ; Microbial Sensitivity Tests*; Surface-Active Agents/chemistry ; Surface-Active Agents/pharmacology ; Humans ; Hydrophobic and Hydrophilic Interactions
    • Abstract:
      Biofilm-associated infections remain a tremendous obstacle to the treatment of microbial infections globally. However, the poor penetrability to a dense extracellular polymeric substance matrix of traditional antibacterial agents limits their antibiofilm activity. Here, we show that nanoaggregates formed by self-assembly of amphiphilic borneol-guanidine-based cationic polymers (BGN x - n ) possess strong antibacterial activity and can eliminate mature Staphylococcus aureus ( S. aureus ) biofilms. The introduction of the guanidine moiety improves the hydrophilicity and membrane penetrability of BGN x - n . The self-assembled nanoaggregates with highly localized positive charges are expected to enhance their interaction with negatively charged bacteria and biofilms. Furthermore, nanoaggregates dissociate on the surface of biofilms into smaller BGN x - n polymers, which enhances their ability to penetrate biofilms. BGN x - n nanoaggregates that exhibit superior antibacterial activity have the minimum inhibitory concentration (MIC) of 62.5 μg·mL -1 against S. aureus and eradicate mature biofilms at 4 × MIC with negligible hemolysis. Taken together, this size-variable self-assembly system offers a promising strategy for the development of effective antibiofilm agents.
    • Contributed Indexing:
      Keywords: (+)-borneol; biofilm; guanidine; natural products; self-assembly
    • Accession Number:
      0 (Anti-Bacterial Agents)
      JU58VJ6Y3B (Guanidine)
      0 (Camphanes)
      0 (Polymers)
      L88RA8N5EG (isoborneol)
      0 (Surface-Active Agents)
    • Publication Date:
      Date Created: 20240629 Date Completed: 20240725 Latest Revision: 20240725
    • Publication Date:
      20240726
    • Accession Number:
      10.1021/acsami.4c02818
    • Accession Number:
      38943568