The triggering pathway, the metabolic amplifying pathway, and cellular transduction in regulation of glucose-dependent biphasic insulin secretion.

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  • Author(s): Bisht S;Bisht S; Singh MF; Singh MF
  • Source:
    Archives of physiology and biochemistry [Arch Physiol Biochem] 2024 Dec; Vol. 130 (6), pp. 854-865. Date of Electronic Publication: 2024 Jan 09.
  • Publication Type:
    Journal Article; Review
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: Informa Healthcare Country of Publication: England NLM ID: 9510153 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1744-4160 (Electronic) Linking ISSN: 13813455 NLM ISO Abbreviation: Arch Physiol Biochem Subsets: MEDLINE
    • Publication Information:
      Publication: London : Informa Healthcare
      Original Publication: Lisse, Netherlands : Swets & Zeitlinger, c1995-
    • Subject Terms:
      Insulin Secretion*/drug effects ; Glucose*/metabolism ; Insulin-Secreting Cells*/metabolism ; Insulin*/metabolism; Humans ; Animals ; Signal Transduction ; Exocytosis ; KATP Channels/metabolism ; Adenosine Triphosphate/metabolism ; Calcium/metabolism
    • Abstract:
      Introduction: Insulin secretion is a highly regulated process critical for maintaining glucose homeostasis. This abstract explores the intricate interplay between three essential pathways: The Triggering Pathway, The Metabolic Amplifying Pathway, and Cellular Transduction, in orchestrating glucose-dependent biphasic insulin secretion.
      Mechanism: During the triggering pathway, glucose metabolism in pancreatic beta-cells leads to ATP production, closing ATP-sensitive potassium channels and initiating insulin exocytosis. The metabolic amplifying pathway enhances insulin secretion via key metabolites like NADH and glutamate, enhancing calcium influx and insulin granule exocytosis. Additionally, the cellular transduction pathway involves G-protein coupled receptors and cyclic AMP, modulating insulin secretion.
      Result and Conclusion: These interconnected pathways ensure a dynamic insulin response to fluctuating glucose levels, with the initial rapid phase and the subsequent sustained phase. Understanding these pathways' complexities provides crucial insights into insulin dysregulation in diabetes and highlights potential therapeutic targets to restore glucose-dependent insulin secretion.
    • Contributed Indexing:
      Keywords: Beta cells; biphasic insulin secretion; cellular transduction; glucose sensing; metabolic amplifying pathway; triggering pathway
    • Accession Number:
      IY9XDZ35W2 (Glucose)
      0 (Insulin)
      0 (KATP Channels)
      8L70Q75FXE (Adenosine Triphosphate)
      SY7Q814VUP (Calcium)
    • Publication Date:
      Date Created: 20240110 Date Completed: 20241203 Latest Revision: 20241206
    • Publication Date:
      20241209
    • Accession Number:
      10.1080/13813455.2023.2299920
    • Accession Number:
      38196246