The association of ideal cardiovascular health metrics and incident hypertension among an urban population of Iran: a decade follow-up in Tehran Lipid and Glucose Study.

Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8811625 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5527 (Electronic) Linking ISSN: 09509240 NLM ISO Abbreviation: J Hum Hypertens Subsets: MEDLINE

Publication: <2003->: London : Nature Publishing Group
Original Publication: Houndmills, Basingstoke, Hampshire, UK : Scientific & Medical, Macmillan Press, c1987-

Glucose* ; Hypertension*/diagnosis ; Hypertension*/epidemiology ; Hypertension*/complications; Adult ; United States ; Humans ; Female ; Male ; Iran/epidemiology ; Follow-Up Studies ; Quality Indicators, Health Care ; Urban Population ; Blood Pressure ; Cholesterol ; Risk Factors

We aimed to determine the association between ideal cardiovascular health metrics (ICVHM) and the incidence of hypertension among Iranian adults. The study population included 5409 Iranian adults aged ≥20 years (2088 men) without hypertension (applying the 2017 American College of Cardiology (ACC)/American Heart Association (AHA) guideline) at baseline. The ICVHM was defined according to the AHA's 2020 impact goals, excluding total cholesterol was replaced by non-HDL cholesterol (non-HDL-C). Multivariable Cox proportional hazards regression analysis was done to estimate the hazard ratios (HRs) for ICVHM both as continuous and categorical variables. During a median 8.5-year follow-up, 2972 new cases of hypertension were identified (men: 1,287). Non-HDL-C < 130 mg/dL in men [HR (95% CI): 0.75(0.65-0.86)] and fasting plasma glucose(FPG) < 100 mg/dL in women[HR (95% CI): 0.79(0.64-0.97)], and among both genders, being normal/overweigth status (compared to obese) and blood pressure <120/80 mmHg were associated with a lower risk for hypertension. Additionally, in both gender, a 1-point increase in the number of global ICVHM decreased the risk of hypertension by more than 10%, and having ≥5 vs. <2 ICVHM, were associated with a lower risk of hypertension by 30% (all p values < 0.05). Applying the JNC 7 guideline, the association between ICVHM, with incident hypertension, were generally similar. Having a higher number of ICVHM was associated with a lower risk of incident hypertension, using both 2017 ACC/AHA and JNC 7 guidelines, mostly attributable to keeping the ideal status of body mass index, non-HDL-C, and FPG.
(© 2023. The Author(s), under exclusive licence to Springer Nature Limited.)

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IY9XDZ35W2 (Glucose)
97C5T2UQ7J (Cholesterol)

Date Created: 20231219 Date Completed: 20240318 Latest Revision: 20240417

20240418

10.1038/s41371-023-00881-3

38110597