Melanotic Neuroectodermal Tumour of Infancy.

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  • Additional Information
    • Source:
      Publisher: Country of Publication: United States NLM ID: 101304010 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1936-0568 (Electronic) Linking ISSN: 1936055X NLM ISO Abbreviation: Head Neck Pathol Subsets: MEDLINE
    • Publication Information:
      Publication: June 2011- : New York : Springer Science+ Business Media
      Original Publication: Secaucus, NJ : Humana Press
    • Subject Terms:
      Neuroectodermal Tumor, Melanotic*/diagnosis ; Neuroectodermal Tumor, Melanotic*/pathology ; Neuroectodermal Tumor, Melanotic*/surgery; Child ; Humans ; Infant ; Maxilla/pathology ; Neck/pathology ; Diagnosis, Differential ; Head/pathology
    • Abstract:
      Melanotic neuroectodermal tumour of infancy (MNTI) is a locally aggressive neoplasm of neural crest origin. It is primarily a paediatric tumour, and 95% of the cases occur in children below 1 year. The tumour mainly affects the head and neck region. It shows a predilection for the craniofacial sites and the most common site affected is anterior maxilla. Microscopically, it is characterized by a biphasic population of neuroblastic cells and pigmented epithelial cells. Although generally considered as a benign tumour, it can invade the adjacent muscle and bone, causing destruction of the involved site. The rapidity in growth and the aggressive clinical behaviour of the tumour can be deceptive and hence lack of familiarity with the clinical characteristics of the tumour may often lead to an erroneous diagnosis of malignancy. The treatment of choice for MNTI is excision, and it is usually curative. Extensive surgery in a child may interfere with the normal growth and development of the facial structures and reconstruction can be very challenging in infants. Hence, early diagnosis is critical for the effective management. Clinical findings, histopathological features, and differential diagnosis of a classic case of melanotic neuroectodermal tumour of infancy are discussed.
      (© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
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    • Contributed Indexing:
      Keywords: Early diagnosis; Infant; Maxilla; Melanotic; Neural crest; Neuroectodermal tumour
    • Publication Date:
      Date Created: 20230228 Date Completed: 20230628 Latest Revision: 20240229
    • Publication Date:
      20240229
    • Accession Number:
      PMC10293543
    • Accession Number:
      10.1007/s12105-023-01537-x
    • Accession Number:
      36853558