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Rapid determination and optimisation of berberine from Himalayan Berberis lycium by soxhlet apparatus using CCD-RSM and its quality control as a potential candidate for COVID-19.
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- Author(s): Katare AK;Katare AK; Singh B; Singh B; Shukla P; Shukla P; Gupta S; Gupta S; Singh B; Singh B; Yalamanchili K; Yalamanchili K; Kulshrestha N; Kulshrestha N; Bhanwaria R; Bhanwaria R; Sharma AK; Sharma AK; Sharma S; Sharma S; Sneha; Sneha; Mindala DP; Mindala DP; Roy S; Roy S; Kalgotra R; Kalgotra R
- Source:
Natural product research [Nat Prod Res] 2022 Feb; Vol. 36 (3), pp. 868-873. Date of Electronic Publication: 2020 Aug 13.- Publication Type:
Journal Article- Language:
English - Source:
- Additional Information
- Source: Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE
- Publication Information: Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003-
- Subject Terms:
- Abstract: SARS-CoV-2 (or COVID-19) has become a global risk and scientists are attempting to investigate antiviral vaccine. Berberis are important plants due to the presence of bioactive phytochemicals, especially berberine from the protoberberine group of benzylisoquinoline and recent studies have shown its potential in treating COVID-19. B. lycium Royle growing in subtropical regions of Asia had wide applications in Indian system of medicine. Rapid determination and novel optimisation method for berberine extraction has been developed by Soxhlet extraction utilising central composite design-response surface methodology (CCD-RSM). Berberine was detected by high-performance liquid chromatography (HPLC), and the highest yield (13.39%) was obtained by maintaining optimal extraction conditions i.e., extraction time (7.28 hrs), ethyl alcohol (52.21%) and solvent to sample ratio (21.78 v/w). Investigation of two geographic regions (Ramnagar and Srinagar) showed high berberine content in lower altitude. This novel optimisation technique has placed berberine as a potential candidate for developing pharmaceutical products for human health care.
- Contributed Indexing: Keywords: Berberine; CCD-RSM; COVID-19; Soxhlet extraction
- Accession Number: 0 (Plant Extracts)
0I8Y3P32UF (Berberine) - Publication Date: Date Created: 20200814 Date Completed: 20220125 Latest Revision: 20220125
- Publication Date: 20240628
- Accession Number: 10.1080/14786419.2020.1806274
- Accession Number: 32787584
- Source:
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