Synchronous bilateral breast cancer: a nationwide study on histopathology and etiology.

Item request has been placed! ×
Item request cannot be made. ×
loading   Processing Request
Read More Add to Saved list
  • Additional Information
    • Source:
      Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE
    • Publication Information:
      Publication: Dordrecht : Kluwer Academic
      Original Publication: The Hague ; Boston : M. Nijhoff, c1981-
    • Subject Terms:
      Breast Neoplasms/*etiology ; Breast Neoplasms/*pathology ; Neoplasms, Multiple Primary/*etiology ; Neoplasms, Multiple Primary/*pathology; Aged ; Breast Neoplasms/epidemiology ; Carcinoma, Ductal, Breast/epidemiology ; Carcinoma, Ductal, Breast/etiology ; Carcinoma, Ductal, Breast/pathology ; Carcinoma, Lobular/epidemiology ; Carcinoma, Lobular/etiology ; Carcinoma, Lobular/pathology ; Denmark/epidemiology ; Female ; Follow-Up Studies ; Humans ; Middle Aged ; Neoplasm Invasiveness ; Neoplasm Staging ; Neoplasms, Multiple Primary/epidemiology ; Receptor, ErbB-2/metabolism ; Receptors, Estrogen/metabolism ; Receptors, Progesterone/metabolism
    • Abstract:
      Purpose: The aim of the present study was to describe histopathologic characteristics of synchronous bilateral breast cancer (SBBC), and by comparing SBBC to unilateral breast cancer (UBC), identify possible etiological mechanisms of SBBC.
      Methods: Patients with primary SBBC (diagnosed within 4 months) and UBC diagnosed in Denmark between 1999 and 2015 were included. Detailed data on histopathology were retrieved from the Danish Breast Cancer Group database and the Danish Pathology Register. Associations between bilateral disease and the different histopathologic characteristics were evaluated by odds ratios and estimated by multinomial regression models.
      Results: 1214 patients with SBBC and 59,221 with UBC were included. Patients with SBBC more often had invasive lobular carcinomas (OR 1.29; 95% CI 1.13-1.47), a clinically distinct subtype of breast cancer, than UBC patients. Further, they were older than UBC patients, more often had multifocal cancer (OR 1.13; 95% CI 1.01-1.26), and a less aggressive subtype than UBC patients. Invasive lobular carcinoma was associated with having multiple tumors in breast tissue-both in the form of bilateral disease and multifocal disease, and this association was independent of laterality. No similar pattern was observed for other tumor characteristics.
      Conclusion: We identified two etiological mechanisms that could explain some of the occurrence of SBBC. The high proportion of less aggressive carcinomas and higher age of SBBC compared to UBC patients suggests that many are diagnosed at a subclinical stage as slow-growing tumors have a higher probability of simultaneous diagnosis. The high proportion of invasive lobular carcinoma observed in bilateral and multifocal disease, being independent of laterality, suggests that these patients have an increased propensity to malignant tumor formation in breast tissue.
    • Grant Information:
      R124-A7440-15-S2 Kræftens Bekæmpelse
    • Contributed Indexing:
      Keywords: Cohort study; Etiology; Histopathology; Invasive lobular carcinoma; Multifocal breast cancer; Synchronous bilateral breast cancer
    • Accession Number:
      0 (Receptors, Estrogen)
      0 (Receptors, Progesterone)
      EC 2.7.10.1 (ERBB2 protein, human)
      EC 2.7.10.1 (Receptor, ErbB-2)
    • Publication Date:
      Date Created: 20200523 Date Completed: 20210104 Latest Revision: 20210104
    • Publication Date:
      20221213
    • Accession Number:
      10.1007/s10549-020-05689-0
    • Accession Number:
      32441019