[Adenosine and its role in physiology].

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  • Author(s): Novotný J
  • Source:
    Ceskoslovenska fysiologie [Cesk Fysiol] 2015; Vol. 64 (1), pp. 35-44.
  • Publication Type:
    Journal Article; Review
  • Language:
    Slovak
  • Additional Information
    • Transliterated Title:
      Adenosin a jeho role ve fyziologii.
    • Source:
      Publisher: Ceska Lekarska Spolecnost J.E. Purkyne Country of Publication: Czech Republic NLM ID: 2984710R Publication Model: Print Cited Medium: Print ISSN: 1210-6313 (Print) Linking ISSN: 12106313 NLM ISO Abbreviation: Cesk Fysiol Subsets: MEDLINE
    • Publication Information:
      Publication: <1995- >: Praha : Ceska Lekarska Spolecnost J.E. Purkyne
      Original Publication: Praha : Prírodovedecké vydavatelství, 1952-
    • Subject Terms:
      Signal Transduction*; Adenosine/*physiology; Humans ; Nucleoside Transport Proteins/metabolism ; Receptors, Purinergic P1/metabolism
    • Abstract:
      Adenosine is not just a major component of adenine nucleotides and ribonucleic acids, but also has its own signaling functions. ExtraceIlular level of adenosine in an organism is strictly maintained through the balance between its formation, degradation and transport. Adenosine is formed by enzymatic degradation of adenosine triphosphate and eliminated by phosphorylation to adenosine monophosphate or by deamination to inosine. Transport of adenosine across the cell membrane is ensured by equilibrative and concentrative nucleoside transporters. All these processes participate in maintenance of adenosine level under normal conditions, but a balanced equilibrium can be disrupted in some pathophysiological situations. Extracellular adenosine as a signaling molecule binds to adenosine receptors, which may trigger via their cognate trimeric G proteins different signaling pathways. In this way, adenosine regulates energy homeostasis and affects the function of various organs. Targeted pharmacological manipulations of specific adenosine receptor subtypes or enzymes involved in its metabolism can potentially be used for therapeutic purposes.
    • Accession Number:
      0 (Nucleoside Transport Proteins)
      0 (Receptors, Purinergic P1)
      0 (adenosine transporter)
      K72T3FS567 (Adenosine)
    • Publication Date:
      Date Created: 20160108 Date Completed: 20161213 Latest Revision: 20161230
    • Publication Date:
      20221213
    • Accession Number:
      26738245