Theoretical and experimental study of ON-Resonance Saturation, an MRI sequence for positive contrast with superparamagnetic nanoparticles.

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  • Additional Information
    • Source:
      Publisher: Elsevier Country of Publication: United States NLM ID: 9707935 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1096-0856 (Electronic) Linking ISSN: 10907807 NLM ISO Abbreviation: J Magn Reson Subsets: MEDLINE
    • Publication Information:
      Publication: 2004- : San Diego : Elsevier
      Original Publication: San Diego : Academic Press, c1997-2004.
    • Subject Terms:
      Algorithms*; Brain/*anatomy & histology ; Contrast Media/*chemistry ; Dextrans/*chemistry ; Image Interpretation, Computer-Assisted/*methods ; Magnetic Resonance Imaging/*methods ; Magnetite Nanoparticles/*chemistry; Computer Simulation ; Humans ; Image Enhancement/methods ; Magnetic Resonance Imaging/instrumentation ; Models, Biological ; Phantoms, Imaging ; Reproducibility of Results ; Sensitivity and Specificity ; Signal Processing, Computer-Assisted
    • Abstract:
      Superparamagnetic iron oxide nanoparticles (SPM particles) are widely used in MRI as negative contrast agents. Their detection is sometimes difficult because negative contrast can be caused by different artifacts. To overcome this problem, MRI protocols achieving positive contrast specific to SPM particles were developed such as the ON-Resonance Saturation (ONRS) sequence. The aim of the present work is to achieve a bottom-up study of the ONRS sequence by an understanding of the physical mechanisms leading to positive contrast. A complete theoretical modeling, a novel numerical simulation approach and experiments on agarose gel phantoms on a 11.7 T MRI system were carried out for this purpose. The influence of the particle properties and concentration - as well as the effect of the sequence parameters on the contrast - were investigated. It was observed that theory and experiments were in strong agreement. The tools developed in this work allowed to predict the parameters leading to the maximum contrast. For example, particles presenting a low transverse relaxivity can provide an interesting positive contrast after optimization of their concentration in the sample.
      (Copyright © 2015 Elsevier Inc. All rights reserved.)
    • Contributed Indexing:
      Keywords: Contrast agents; Iron oxide nanoparticles; Magnetic resonance imaging; Off-resonance imaging; Positive contrast imaging; Superparamagnetic nanoparticles
    • Accession Number:
      0 (Contrast Media)
      0 (Dextrans)
      0 (Magnetite Nanoparticles)
      0 (ferumoxtran-10)
    • Publication Date:
      Date Created: 20150221 Date Completed: 20151214 Latest Revision: 20161125
    • Publication Date:
      20221213
    • Accession Number:
      10.1016/j.jmr.2015.01.007
    • Accession Number:
      25700117