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RK-1355A and B, novel quinomycin derivatives isolated from a microbial metabolites fraction library based on NPPlot screening.
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- Additional Information
- Source:
Publisher: Nature Publishing Group Country of Publication: England NLM ID: 0151115 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1881-1469 (Electronic) Linking ISSN: 00218820 NLM ISO Abbreviation: J Antibiot (Tokyo) Subsets: MEDLINE
- Publication Information:
Publication: 2009- : London : Nature Publishing Group
Original Publication: Tokyo, Japan Antibiotics Research Assn.
- Subject Terms:
- Abstract:
Two novel quinomycin derivatives, RK-1355A (1) and B (2), and one known quinomycin derivative, UK-63,598 (3), were isolated from a microbial metabolites fraction library of Streptomyces sp. RK88-1355 based on Natural Products Plot screening. The structural elucidation of 1 and 2 was established through two-dimensional NMR and mass spectrometric measurements. They belong to a class of quinomycin antibiotics family having 3-hydroxyquinaldic acid and a sulfoxide moiety. They are the first examples for natural products as a quinoline type quinomycin having a sulfoxide on the intramolecular cross-linkage. They showed potent antiproliferative activities against various cancer cell lines and they were also found to exhibit moderate antibacterial activity.
- Accession Number:
0 (Anti-Bacterial Agents)
0 (Antineoplastic Agents)
0 (RK-1355A)
0 (Small Molecule Libraries)
120796-23-8 (UK 63598)
512-64-1 (Echinomycin)
- Publication Date:
Date Created: 20140206 Date Completed: 20140613 Latest Revision: 20140428
- Publication Date:
20221213
- Accession Number:
10.1038/ja.2013.144
- Accession Number:
24496142
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