Discovery of palmatine derivatives as potent neuroprotective agents.

ALZHEIMER'S disease prevention; CHINESE medicine; NEUROPROTECTIVE agents; DRUG toxicity; IN vitro studies; ALZHEIMER'S disease; RESEARCH funding; LIQUID chromatography-mass spectrometry; T-test (Statistics); HERBAL medicine; CELL physiology; NEURODEGENERATION; BIOCHEMISTRY; IMMUNODIAGNOSIS; OXIDATIVE stress; DESCRIPTIVE statistics; MEDICINAL plants; DRUG efficacy; HYDROGEN peroxide; SPECTRUM analysis; BIOLOGICAL assay; STAINS & staining (Microscopy); DRUG discovery; CELL surface antigens; NONPARAMETRIC statistics; PHARMACODYNAMICS

Alzheimer's disease is a neurodegenerative disorder characterized by the presence of neurodegenerative lesions and cognitive impairment. In this study, a series of novel palmatine derivatives were designed and synthesized through the introduction of a heteroatom using carbodiimide-mediated condensation. The synthesized compounds were then screened for toxicity and potency, leading to the identification of compound 2q, which exhibited low toxicity and high potency. Our findings demonstrated that compound 2q displayed significant neuroprotective activity in vitro, emerging as a promising candidate for Alzheimer's disease treatment. [ABSTRACT FROM AUTHOR]

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