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Wando Mount Pleasant Library
11 a.m. - 6 p.m.
Phone: (843) 805-6888
Village Library
11 a.m. - 6 p.m.
Phone: (843) 884-9741
St. Paul's/Hollywood Library
11 a.m. - 6 p.m.
Phone: (843) 889-3300
Otranto Road Library
11 a.m. - 6 p.m.
Phone: (843) 572-4094
Mt. Pleasant Library
11 a.m. – 6 p.m.
Phone: (843) 849-6161
McClellanville Library
11 a.m. - 1 p.m.
Phone: (843) 887-3699
Keith Summey North Charleston Library
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Phone: (843) 744-2489
John's Island Library
11 a.m. - 6 p.m.
Phone: (843) 559-1945
Hurd/St. Andrews Library
11 a.m. - 6 p.m.
Phone: (843) 766-2546
Folly Beach Library
11 a.m. - 1 p.m.
Phone: (843) 588-2001
Miss Jane's Building (Edisto Library Temporary Location)
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Dorchester Road Library
11 a.m. - 6 p.m.
Phone: (843) 552-6466
John L. Dart Library
11 a.m. - 6 p.m.
Phone: (843) 722-7550
Baxter-Patrick James Island
11 a.m. - 6 p.m.
Phone: (843) 795-6679
Main Library
11 a.m. - 6 p.m.
Phone: (843) 805-6930
Bees Ferry West Ashley Library
11 a.m. - 6 p.m.
Phone: (843) 805-6892
West Ashley Library
9 a.m. - 6 p.m.
Phone: (843) 766-6635
Edgar Allan Poe/Sullivan's Island Library
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Phone: (843) 805-6909
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Familial Alzheimer's Disease Neurons Bearing Mutations in PSEN1 Display Increased Calcium Responses to AMPA as an Early Calcium Dysregulation Phenotype.
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- Author(s): Targa Dias Anastacio, Helena; Matosin, Natalie; Ooi, Lezanne
- Source:
Life (2075-1729); May2024, Vol. 14 Issue 5, p625, 30p- Subject Terms:
- Source:
- Additional Information
- Abstract: Familial Alzheimer's disease (FAD) can be caused by mutations in PSEN1 that encode presenilin-1, a component of the gamma-secretase complex that cleaves amyloid precursor protein. Alterations in calcium (Ca2+) homeostasis and glutamate signaling are implicated in the pathogenesis of FAD; however, it has been difficult to assess in humans whether or not these phenotypes are the result of amyloid or tau pathology. This study aimed to assess the early calcium and glutamate phenotypes of FAD by measuring the Ca2+ response of induced pluripotent stem cell (iPSC)-derived neurons bearing PSEN1 mutations to glutamate and the ionotropic glutamate receptor agonists NMDA, AMPA, and kainate compared to isogenic control and healthy lines. The data show that in early neurons, even in the absence of amyloid and tau phenotypes, FAD neurons exhibit increased Ca2+ responses to glutamate and AMPA, but not NMDA or kainate. Together, this suggests that PSEN1 mutations alter Ca2+ and glutamate signaling as an early phenotype of FAD. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Life (2075-1729) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
- Abstract:
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