Ofloxacin and norfloxacin simultaneous detection by ERGO/GCE and its application in medicine and aquaculture wastewater.

Ofloxacin (OFLX) and norfloxacin (NFLX) are typical quinolone antibacterials used in medicine, aquaculture, and animal husbandry in China. The abusive use of antibiotics has led to the presence of OFLX and NFLX in surface water and groundwater. Due to similarities in the molecular structure of OFLX and NFLX, their simultaneous detection has been challenging. In this study, a simple and highly sensitive electrochemical sensor for the simultaneous detection of OFLX and NFLX was developed using a graphene modified glassy carbon electrode (ERGO/GCE), which was prepared by the electrochemical reduction method. With electrochemical reduction, oxygen-containing groups in graphene oxide (GO) were deoxidized to electrochemically reduced graphene oxide (ERGO) and can effectively separate the overlapping oxidation peaks of OFLX and NFLX with a 136 mV peak potential difference. The mechanism of these oxidation processes was analyzed by comparing the Fourier transform infrared (FTIR) of OFLX and NFLX electrochemical response on prepared modified electrodes. The limitations of this electrochemical method in terms of simultaneous detection are as follows: 1.25 μM for OFLX and 2.44 μM for NFLX. This detection method was also applied in medicine and aquaculture wastewater with satisfactory results. [ABSTRACT FROM AUTHOR]

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