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Efficacy of methylergometrine during the early puerperium: a randomized double-blind placebo-controlled clinical trial.
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- Author(s): Sparice, Stefania; Giampaolino, Pierluigi; Sansone, Anna; Saccone, Gabriele; Berghella, Vincenzo; Di Carlo, Costantino
- Source:
Journal of Maternal-Fetal & Neonatal Medicine; May2020, Vol. 33 Issue 10, p1744-1748, 5p- Subject Terms:
CLINICAL trials; PUERPERIUM; HEMOGLOBINS; UNIVERSITY hospitals; PREGNANCY; UTERINE hemorrhage; RESEARCH; ERGOMETRINE; ORAL drug administration; RESEARCH methodology; EVALUATION research; MEDICAL cooperation; COMPARATIVE studies; RANDOMIZED controlled trials; BLIND experiment; DELIVERY (Obstetrics); OXYTOCICS - Source:
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- Abstract: Objective: To determine if oral methylergometrine administration during the first 10 d following spontaneous vaginal delivery has any beneficial effect on the increase of hemoglobin levels.Methods: This was a parallel group double-blind placebo-controlled clinical trial conducted at single center university hospital in Italy. Participants were puerperal women, who delivered singleton gestation with spontaneous vaginal delivery at term. Participants were randomized into a 1:1 ratio to receive either 0.125âmg methylergometrine per os twice a day or placebo for 10 d. Hemoglobin levels were recorded on the day of delivery and after 10 d. The primary outcome was the variation in hemoglobin levels between the first and the 10th day of treatment.Results: From December 2012 to October 2015, 220 agreed to take part in the study, underwent randomization, and were enrolled and followed-up. Of the randomized women, 110 (50%) were randomized to the methylergometrine group and 110 (50%) to the placebo group. No women were excluded after randomization or lost to follow-up (100%). We found no significant difference in the median variation of hemoglobin levels between the intervention and the placebo groupConclusions: The use of 10 d oral methylergometrine in puerperal women was not associated with any benefit in the variation of hemoglobin levels from delivery to 10 d after delivery.Key MessageMethylergometrine in puerperal women was not associated with any benefit. [ABSTRACT FROM AUTHOR]
- Abstract: Copyright of Journal of Maternal-Fetal & Neonatal Medicine is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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