Occupational asthma and contact dermatitis in a spray painter after introduction of an aziridine cross-linker.

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  • Author(s): Leffler CT;Leffler CT; Milton DK
  • Source:
    Environmental health perspectives [Environ Health Perspect] 1999 Jul; Vol. 107 (7), pp. 599-601.
  • Publication Type:
    Case Reports; Clinical Conference; Journal Article
  • Language:
    English
  • Additional Information
    • Source:
      Publisher: National Institute of Environmental Health Sciences Country of Publication: United States NLM ID: 0330411 Publication Model: Print Cited Medium: Print ISSN: 0091-6765 (Print) Linking ISSN: 00916765 NLM ISO Abbreviation: Environ Health Perspect Subsets: MEDLINE
    • Publication Information:
      Original Publication: Research Triangle Park, N. C. National Institute of Environmental Health Sciences.
    • Subject Terms:
      Paint*; Asthma/*chemically induced ; Aziridines/*adverse effects ; Dermatitis, Contact/*etiology ; Occupational Diseases/*chemically induced; Adult ; Humans ; Male
    • Abstract:
      A 23-year-old spray painter developed contact dermatitis and respiratory difficulty characterized by small airways obstruction shortly after the polyfunctional aziridine cross-linker CX-100 began to be used in his workplace as a paint activator. The symptoms resolved after he was removed from the workplace and was treated with inhaled and topical steroids. Painters may have an increased risk of asthma due to exposure to a variety of agents, such as isocyanates, alkyd resins, and chromates. This case illustrates the importance of using appropriate work practices and personal protective equipment to minimize exposure. Occupational asthma is diagnosed by a history of work-related symptoms and exposure to known causative agents. The diagnosis is confirmed by serial pulmonary function testing or inhalational challenge testing. The risk of asthma attributable to occupational exposures is probably underappreciated due to underreporting and to inappropriate use of narrow definitions of exposure in epidemiologic studies of attributable risk.
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    • Accession Number:
      0 (Aziridines)
      54P5FEX9FH (aziridine)
    • Publication Date:
      Date Created: 19990624 Date Completed: 19990729 Latest Revision: 20181113
    • Publication Date:
      20221213
    • Accession Number:
      PMC1566653
    • Accession Number:
      10.1289/ehp.99107599
    • Accession Number:
      10379008