1721 – South Carolina becomes a royal colony. General Sir Francis Nicholson made Governor.

1728 – Regular passenger and shipping service begins between Charles Town and New York.

1728 – Hurricane of 1728

1729 – (July 25) King George buys out the Lords Proprietors, finalizing South Carolina's transformation into a Royal Colony.

1732 – (Jan 8) The South Carolina Gazette publishes its first edition.

1732 – (April 19) The first known concert in Charles Town is performed by John Salter, organist of St. Philip's.

1733 – (Jan. 13) James Oglethorpe and the first settlers for Georgia arrive in Charles Town Harbor on the Anne. Savannah is founded soon after.

1734 – (Feb 2) After the death of its first editor, The South Carolina Gazette resumes publication under Lewis Timothy, who is backed by Ben Franklin.

1735 – To see an illustration of Charles Town in 1735, click here.

1735 – (Feb 18) The first public presentation of an opera in the colonies is performed at Broad and Church.

1736 – (Feb. 3) Organization of America's first fire insurance company.

1736 – One of the first theatres in the country, The Dock Street, opens with The Recruiting Officer.

1739 – (Sept 9) Some 40 blacks and 21 whites are killed during a slave revolt along the Stono River.

1740 – Fire rages through the waterfront district.

1740 – (April 28) News arrives of war against Spain, and plans are made to attack St. Augustine.

1740 – Construction of the East Bay warehouse district, today known as Rainbow Row.

1742 – Charles Town's population estimated to be 6,800.

1742 – To see an illustration of Charles Town in 1742, click here.

1745 – Lots laid out for Ansonborough neighborhood.

1747 – (April 18) City leaders sign a treaty with Choctaw Indians establishing trade in return for their attacking French settlements.

1748 – (Dec 28) A group of citizens form the Charleston Library Society, a subscription library still in existance.

1751 – (June 14) City is divided into two parishes: St. Michael's south of Broad, and St. Philip's north of Broad.

1752 – (Sept) Great Hurricane of 1752 devastates the city, killing nearly a hundred.

1761 – (Feb. 1) First services are held at St. Michael's Church, the oldest surviving church building in the city.

1767 – The Old Exchange Building is built on the ruins of Half-Moon Battery, the site of the former Court of Guard.

1770 – (July 5) A statue of William Pitt, believed the first commemorating a public figure in America, is dedicated at Meeting and Broad.

1770 – Development of Harleston Village neighborhood.

1773 – (Jan. 12) A committee of The Library Society establishes the Charleston Museum – the oldest in the country.